Salta al contenuto principale
Passa alla visualizzazione normale.

RAFFAELLA MELFI

Curriculum e ricerca

Insegnamenti

Anno accademico Codice della materia Nome della materia CFU Corso di studi
2023/2024 16130 TECNOLOGIE RICOMBINANTI 6 BIOTECNOLOGIE

Pubblicazioni

Data Titolo Tipologia Scheda
2023 Controlled uptake of PFOA in adult specimens of Paracentrotus lividus and evaluation of gene expression in their gonads and embryos Articolo in rivista Vai
2023 Site-Specific RNA Editing of Stop Mutations in the CFTR mRNA of Human Bronchial Cultured Cells Articolo in rivista Vai
2023 Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression Articolo in rivista Vai
2023 RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis Abstract in atti di convegno pubblicato in volume Vai
2023 Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR Articolo in rivista Vai
2022 P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. Contributo in atti di convegno pubblicato in rivista Vai
2022 Uptake and photoinduced degradation of phthalic acid esters (PAEs) in Ulva lactuca highlight its potential application in environmental bioremediation Articolo in rivista Vai
2022 Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation Articolo in rivista Vai
2022 Phylogenetic affinities of the Italian population of Eastern Montpellier snake, Malpolon insignitus (Serpentes: Lamprophiidae) Articolo in rivista Vai
2022 Preliminary genetic characterisation of Southern Smooth Snake Coronella girondica (Serpentes, Colubridae) populations in Italy, with some considerations on their alpine distribution Articolo in rivista Vai
2022 Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation Abstract in atti di convegno pubblicato in volume Vai
2022 Impact of Heavy Metals in Eggs and Tissues of C. caretta along the Sicilian Coast (Mediterranean Sea) Articolo in rivista Vai
2021 Presence and biodistribution of perfluorooctanoic acid (PFOA) in Paracentrotus lividus highlight its potential application for environmental biomonitoring Articolo in rivista Vai
2021 Can phthalates move into the eggs of the loggerhead sea turtle Caretta caretta? The case of the nests on the Linosa Island in the Mediterranean Sea Articolo in rivista Vai
2020 The genetic identity of the only Italian population of the genus Macroprotodon Guichenot, 1850 on the island of Lampedusa, Sicily Articolo in rivista Vai
2020 Phylogenetic relationships of the italian populations of horseshoe whip snake hemorrhois hippocrepis (Serpentes, colubridae) Articolo in rivista Vai
2020 Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) Articolo in rivista Vai
2020 Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon Contributo in atti di convegno pubblicato in rivista Vai
2020 Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons Articolo in rivista Vai
2020 Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems Articolo in rivista Vai
2019 Caffeine boosts Ataluren's readthrough activity Articolo in rivista Vai
2019 Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) Review essay (rassegna critica) Vai
2018 OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS Brevetto Vai
2018 Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs Articolo in rivista Vai
2017 Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Poster pubblicato in volume Vai
2017 Tracking the invasion of the red swamp crayfish Procambarus clarkii (Girard, 1852) (Decapoda Cambaridae) in Sicily: a “citizen science” approach Articolo in rivista Vai
2016 Identification of a putative regulator of early-histone gene expression of Paracentrotus lividus Abstract in atti di convegno pubblicato in volume Vai
2016 Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening Articolo in rivista Vai
2016 Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells Abstract in atti di convegno pubblicato in volume Vai
2016 Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells Abstract in rivista Vai
2015 Identification of a putative GAGA factor in P. lividus embryos eedings Vai
2015 Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells eedings Vai
2015 Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives Articolo in rivista Vai
2015 Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. eedings Vai
2015 Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons Articolo in rivista Vai
2014 Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay Articolo in rivista Vai
2014 Reevaluating the function of a transcription factor: MBF-1 as a sea urchin chromatin organizer ? eedings Vai
2014 Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells eedings Vai
2013 PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS eedings Vai
2013 AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) eedings Vai
2013 The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo Articolo in rivista Vai
2013 Valutazione dell'azione readthorough della molecola PTC124 su sistemi modello cellulari contenenti mutazioni non senso e in cellule epiteliali bronchiali IB3.1 (delF508/W1282X) derivate da pazienti affetti da fibrosi cistica. eedings Vai
2013 PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene eedings Vai
2012 X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS. eedings Vai
2011 PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. eedings Vai
2009 The sea urchin histone H2A enhancer-binding protein MBF-1 is needed for maximal expression also for the H3 gene, while is buffered by the sns5 insulator on its interaction with the downstream H1 promoter. eedings Vai
2009 Enhancer, chromatin insulator, non-coding RNA and α-histone gene expression during embryogenesis of the sea urchin Paracentrotus lividus. eedings Vai
2009 Promoter activity of the sea urchin (Paracentrotus lividus) nucleosomal H3 and H2A and linker H1 a-histone genes is modulated by enhancer and chromatin insulator Articolo in rivista Vai
2007 Characterization of a nuclear factor associated to the chromatin of sea urchin histone genes eedings Vai
2007 Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin alpha-H2A Histone Gene Articolo in rivista Vai
2006 CHOMATIN DYNAMIC AND REGULATION OF GENE EXSPRESSION IN THE SEA URCHIN EMBRYO eedings Vai
2006 Dinamica della cromatina nella regolazione del gene con homeobox Hbox12 in P. lividus. eedings Vai
2005 “Epigenetics of silencing of Paracentrotus lividus α-H2A gene” eedings Vai
2004 Down-regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5’ and 3’ regions including the enhancer blocker sns Articolo in rivista Vai
2004 Ruolo delle HDAC sul silenziamento genico nell’embrione di riccio di mare eedings Vai
2004 LA DINAMICA DELLA CROMATINA NELLA REGOLAZIONE DELL’ESPRESSIONEGENICA DELL’EMBRIONE DI RICCIO DI MARE eedings Vai
2004 Down regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5’ and 3’ regions and including the enhancer blocker sns Articolo in rivista Vai
2003 Assembly of Polycomb complexes and silencing mechanisms Articolo in rivista Vai
2002 Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites Articolo in rivista Vai
2001 The sea urchin sns insulator blocks CMV enhancer following integration in human cells Articolo in rivista Vai
2001 Establishment of Polycomb silencing requires a transient interaction between PC and ESC Articolo in rivista Vai
2000 Functional characterization of the enhancer blocking element of the sea urchin early histone gene cluster reveals insulator properties and three essential cis-acting sequences Articolo in rivista Vai
2000 Homeobox genes and sea urchin development Articolo in rivista Vai
1999 Spatially restricted expression of PlOtp, a Paracentrotus lividus Orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos Articolo in rivista Vai
1999 Regulation of the sea urchin early H2A histone gene expression depends on the modulator element and on sequences located near the 3' end Articolo in rivista Vai
1997 Gene expression during early embryogenesis of sea urchin: The histone and homeobox genes Contributo in atti di convegno pubblicato in rivista Vai
1997 Enhancer blocking activity located near the 3′ end of the sea urchin early H2A histone gene Articolo in rivista Vai
1997 Sea urchin HSF activity in vitro and in transgenic embryos Articolo in rivista Vai
1995 Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo Articolo in rivista Vai
1994 Expression of homeobox-containing genes in the sea urchin (Parancentrotus lividus) embryo Articolo in rivista Vai