Atractyligenin chemistry. Part 4: Synthesis of the 15β-ol epimer of atractyligenin
- Autori: Camarda L.; Ceraulo L.; Di Stefano V.; Ferrugia M.
- Anno di pubblicazione: 1996
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/445406
Abstract
The oxidation with PCC of atractyligenin 3, the aglicone of the toxic glycoside 1 isolated from Atractylis gummifera L., led to the 15-oxo-derivative 6, together with a small amount of 2,15-dioxoderivative 5, with a selective oxidation of the allylic 15-OH group of the molecule. Further reduction with NaBH4 and KOH hydrolysis gave stereoselectively the 15β-ol epimer of atractiligenin 9.