Occurrence & Risk of OTA in Food and Feed

Abstract

Ochratoxin A (OTA) is a ubiquitous mycotoxin produced mainly by fungal species of the genera Aspergillus and Penicillium, detected worldwide in various food and feed sources and represents a potential human health hazard. OTA is nephrotoxic and is suspected of being the main etiological agent responsible for human Balkan endemic nephropathy (BEN) and associated urinary tract tumours. International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen (group 2B). The mycotoxin ochratoxin A (OTA) is the most important and most common member among several structurally related ochratoxins. It is a secondary metabolite produced mainly by the following three fungal species Aspergillus alutaceus (formerly known as A. ochraceus), A. carbonarius, and Penicillium verrucosum (EFSA, 2006). Cereals and cereal by-products constitute a major part of the daily diet of the human and animal populations. The total annual yields of cereals globally add up to more than 2000 million tons. Because they are easy to package and transport, they are used for producing a large variety of highly desirable foods, beverages and feed. However, an investigation on a worldwide scale showed that 25% to 40% of cereals are contaminated by mycotoxins (El Khoury and Atoui, 2010). Due to high stability, mycotoxins represent an important problem not only during cereal grain production in field, but also in storage, transport, processing and post-processing steps. This contamination can occur in several times, in the field and/or during storage. It is especially in the countries with hot and wet climatic conditions (in particular African countries, South Asia and South America) that the growth of toxigenic filamentous fungi is most favoured. Thus, rice, corn, and millet, the basic foods of the populations of these countries, are often contaminated by ochratoxins (Nguyen et al., 2007).