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A Multiplex Panel of Plasma Markers of Immunity and Inflammation in Classical Kaposi Sarcoma

  • Autori: Aka, PV; Kemp, TJ; Rabkin, CS; Shiels, MS; Polizzotto, MN; Lauria, C; Vitale, F; Pinto, LA; Goedert, JJ
  • Anno di pubblicazione: 2015
  • Tipologia: Articolo in rivista (Articolo in rivista)
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Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to plasma from 29 matched controls, using a multiplex panel of immunity markers. Of 70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly and significantly associated with KS, after adjustment for age and smoking status. These and previous observations are consistent with a tumor-promoting role for these cytokines, particularly CXCL10, but the small sample size and case-control design preclude firm conclusions on KS risk or pathogenesis. Larger,well-designed prospective studies are needed to better assess the association of these markers with KS.