Still's disease continuum from childhood to elderly: data from the international AIDA Network Still's disease registry
- Autori: Vitale, Antonio; Caggiano, Valeria; Lopalco, Giuseppe; Mayrink Giardini, Henrique A; Ciccia, Francesco; Almaghlouth, Ibrahim A; Ruscitti, Piero; Sfikakis, Petros P; Tufan, Abdurrahman; Dagna, Lorenzo; Giacomelli, Roberto; Hinojosa-Azaola, Andrea; Ragab, Gafaar; Direskeneli, Haner; Fotis, Lampros; Sota, Jurgen; Iannone, Florenzo; Morrone, Maria; de Brito Antonelli, Isabele Parente; Dagostin, Marilia Ambiel; Iacono, Daniela; Patrone, Martina; Asfina, Kazi; Alanazi, Fehaid; Di Cola, Ilenia; Gaggiano, Carla; Tektonidou, Maria G; Kardas, Riza Can; Kucuk, Hamit; Campochiaro, Corrado; Tomelleri, Alessandro; Navarini, Luca; Berardicurti, Onorina; MartÃn-Nares, Eduardo; Torres-Ruiz, Jiram; Mahmoud, Ayman Abdel-Monem Ahmed; Alibaz-Oner, Fatma; Kourtesi, Katerina; Tarsia, Maria; Sfriso, Paolo; Makowska, Joanna; Govoni, Marcello; La Torre, Francesco; Maggio, Maria Cristina; Monti, Sara; Del Giudice, Emanuela; Emmi, Giacomo; Bartoloni, Elena; Hernández-RodrÃguez, José; Gómez-Caverzaschi, Verónica; Maier, Armin; Simonini, Gabriele; Iagnocco, Annamaria; Conti, Giovanni; Olivieri, Alma Nunzia; De Paulis, Amato; Lo Gullo, Alberto; Viapiana, Ombretta; Wiesik-Szewczyk, Ewa; Erten, Sukran; Ogunjimi, Benson; Carubbi, Francesco; Tharwat, Samar; Laskari, Katerina; Costi, Stefania; Triggianese, Paola; Karamanakos, Anastasios; Conforti, Alessandro; Frassi, Micol; Sebastiani, Gian Domenico; Gidaro, Antonio; Mauro, Angela; Balistreri, Alberto; Fabiani, Claudia; Frediani, Bruno; Cantarini, Luca
- Anno di pubblicazione: 2023
- Tipologia: Articolo in rivista
- Parole Chiave: Child; Epidemiology; Still's Disease, Adult-Onset
- OA Link: http://hdl.handle.net/10447/620613
Abstract
Objective: Still's disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still's disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still's disease. Methods: Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still's disease. Results: A total of 411 patients suffering from Still's disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still's disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p<0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p<0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments. Conclusions: Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still's disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still's disease is the same clinical condition arising in different ages.