Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives
- Autori: Maggio, B.; Cancemi, G.; Raimondi, M.V.; Plescia, F.; Cascioferro, S.M.; Cusimano, M.G.; Lauricella, M.; Carlisi, D.; Daidone, G.; Raffa, D.
- Anno di pubblicazione: 2014
- Tipologia: Poster pubblicato in volume
- OA Link: http://hdl.handle.net/10447/98586
Abstract
3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.