A new pericentric inv(8) in acute nonlymphocytic leukemia
- Autori: Santoro, A; Carbone, P; Caradonna, F; Fabbiano, F; Mirto, S; Caronia, F
- Anno di pubblicazione: 1993
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/599276
Abstract
Chromosome studies were carried out on unstimulated bone marrow cells from a patient with a diagnosis of acute nonlymphocytic leukemia (FAB M6 ANLL). Cytogenetic analysis revealed a mosaic chromosome pattern 46,XX/46,XX, inv(8)(p21q24). This pericentric inversion has not been previously described in ANLL. Because, fragile sites, zinc finger gene loci, and the MYC protooncogene have been localized to band 8q24, a putative role for these sites and genes could be considered.