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SILVIO BUSCEMI

Glycaemic variability and inflammation in subjects with metabolic syndrome.

  • Autori: Buscemi, S.; Verga, S.; Cottone, S.; Azzolina, V.; Buscemi, B.; Gioia, D.; Cerasola, G.
  • Anno di pubblicazione: 2009
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: Variabilità glicemica, flogosi, sindrome metabolica
  • OA Link: http://hdl.handle.net/10447/36944

Abstract

Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. The aim of this study was to investigate the glycaemic var- iability measured by continuous glucose monitoring (CGM CV%) in nondiabetic subjects with metabolic syndrome (MS) and to explore if glycaemic variability was associated with circulating levels of interleukin-6 (IL-6), a proinflam- matory cytokine, or with an anti-inflammatory factor like adiponectin. Three groups of obese subjects with (MS?: 6m, 8f; BMI 33.1 ± 1.4 mean ± SEM) or without metabolic syndrome (MS-: 2m, 4f; BMI 29.2 ± 2.2) and with MS associated with type 2 diabetes (MS/T2D: 3m, 5f; BMI 32.9 ± 1.4) were investigated. The glycaemic variability was measured in all subjects in terms of CV% of the gly- caemic values obtained every 3 min during the course of a 48 h CGM performed using a subcutaneous glucose sensor. The average CGM CV% increased from MS- group (21.1%) to the MS? group (23.9%) and to the MS?/T2D group (27.4%) but it was not correlated to the CGM mean glycaemia (r = 0.20; P = ns). In some instances, CGM CV% was found higher in MS? subjects than in some MS? T2D ones. Stepwise multiple correlation analysis showed that IL-6 predicted CGM CV% (R2 = 0.35, b = 0.13; P \ 0.05) independently from BMI, waist circumference, adiponectin and insulin concentrations. In conclusion, the CGM CV% may contribute to better describe the individual metabolic state and to understand the pathogenesis of endothelial dysfunction in non diabetic subjects with MS.