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CIRINO BOTTA

Curriculum e ricerca

Insegnamenti

Anno accademico Codice della materia Nome della materia CFU Corso di studi
2023/2024 57014 MALATTIE DEL SANGUE (MODULO) 3 MEDICINA E CHIRURGIA

Pubblicazioni

Data Titolo Tipologia Scheda
2023 Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma Articolo in rivista Vai
2023 B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma Articolo in rivista Vai
2023 Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma Articolo in rivista Vai
2023 Molecular-Biology-Driven Frontline Treatment for Chronic Lymphocytic Leukemia: A Network Meta-Analysis of Randomized Clinical Trials Articolo in rivista Vai
2023 Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome Articolo in rivista Vai
2023 Unveiling Novel Therapeutic Targets for CAR Therapy in Multiple Myeloma through Single-Cell RNA Sequencing Abstract in rivista Vai
2023 Multiple Myeloma in 2023 Ways: From Trials to Real Life Articolo in rivista Vai
2023 Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again Review essay (rassegna critica) Vai
2023 Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance Articolo in rivista Vai
2023 Immune Cells, Cytokines, and Gut Microbiota Landscape Along Monoclonal Gammopathy of Undetermined Significance (MGUS) to Multiple Myeloma (MM) Evolution Poster pubblicato in rivista Vai
2022 Circulating tumor and immune cells for minimally invasive risk stratification of smoldering multiple myeloma Articolo in rivista Vai
2022 Network meta-analysis of randomized trials in multiple myeloma efficacy and safety in frontline therapy for patients not eligible for transplant Articolo in rivista Vai
2022 Survival Risk Scores for Real-Life Relapsed/Refractory Multiple Myeloma Patients Receiving Elotuzumab or Carfilzomib In Combination With Lenalidomide and Dexamethasone as Salvage Therapy: Analysis of 919 Cases Outside Clinical Trials Articolo in rivista Vai
2022 Elotuzumab plus Lenalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Extended 3-year follow-up of a multicenter, retrospective clinical experience with 319 cases outside of controlled clinical trials Articolo in rivista Vai
2022 In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection Articolo in rivista Vai
2022 PD-1/PD-L1 immune-checkpoint blockade induces immune effector cell modulation in metastatic non-small cell lung cancer patients: A single-cell flow cytometry approach Articolo in rivista Vai
2022 Carfilzomib combined with lenalidomide and dexamethasone (KRd) as salvage therapy for multiple myeloma patients: Italian, multicenter, retrospective clinical experience with 600 cases outside of controlled clinical trials Articolo in rivista Vai
2022 A machine learning model based on tumor and immune biomarkers to predict undetectable MRD and survival outcomes in multiple myeloma Articolo in rivista Vai
2022 Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma Articolo in rivista Vai
2021 Elotuzumab, lenalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: Italian, multicenter, retrospective clinical experience with 300 cases outside of controlled clinical trials Lettera Vai
2021 Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing Articolo in rivista Vai
2021 COVID-19: High-JAKing of the Inflammatory “Flight” by Ruxolitinib to Avoid the Cytokine Storm Articolo in rivista Vai
2021 Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia Articolo in rivista Vai
2021 FlowCT for the analysis of large immunophenotypic datasets and biomarker discovery in cancer immunology Articolo in rivista Vai
2021 Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients Articolo in rivista Vai
2021 miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma Articolo in rivista Vai
2021 Survival risk score for real-life relapsed/refractory chronic lymphocytic leukemia patients receiving ibrutinib. A campus CLL study Lettera Vai
2021 Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies Articolo in rivista Vai
2021 Adjusted comparison between elotuzumab and carfilzomib in combination with lenalidomide and dexamethasone as salvage therapy for multiple myeloma patients Articolo in rivista Vai
2021 Mechanisms of immune evasion in multiple myeloma: Open questions and therapeutic opportunities Articolo in rivista Vai
2021 Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility Articolo in rivista Vai
2021 Assessment of the 4-factor score: Retrospective analysis of 586 CLL patients receiving ibrutinib. A campus CLL study Lettera Vai
2021 Eltrombopag treatment for severe immune thrombocytopenia during pregnancy: a case report Articolo in rivista Vai
2021 Iron Metabolism in the Tumor Microenvironment-Implications for Anti-Cancer Immune Response Articolo in rivista Vai
2021 Philadelphia chromosome-negative myeloproliferative neoplasms in younger adults: A critical discussion of unmet medical needs, with a focus on pregnancy Recensione in rivista Vai
2021 Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation Articolo in rivista Vai
2021 Myositis/myasthenia after pembrolizumab in a bladder cancer patient with an autoimmunity-associated HLA: Immune–biological evaluation and case report Articolo in rivista Vai
2021 Treatment of Lenalidomide Exposed or Refractory Multiple Myeloma: Network Meta-Analysis of Lenalidomide-Sparing Regimens Articolo in rivista Vai
2020 Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After Allogenic Stem Cell Transplant and Dasatinib: A Case Report Articolo in rivista Vai
2020 Radiomics predicts survival of patients with advanced non-small cell lung cancer undergoing PD-1 blockade using Nivolumab Articolo in rivista Vai
2020 Influence of the fabrication accuracy of hot-embossed PCL scaffolds on cell growths Articolo in rivista Vai
2020 Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination Articolo in rivista Vai
2020 Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma Articolo in rivista Vai
2020 Immunologic characterization of COVID-19 patients with hematological cancer Lettera Vai
2020 Immunogenomic identification and characterization of granulocytic myeloid-derived suppressor cells in multiple myeloma Articolo in rivista Vai
2020 An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma Articolo in rivista Vai
2019 Replacement of miR-155 elicits tumor suppressive activity and antagonizes bortezomib resistance in multiple myeloma Articolo in rivista Vai
2019 Could PD-1/PDL1 immune checkpoints be linked to HLA signature? Articolo in rivista Vai
2019 GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up Articolo in rivista Vai
2019 Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma Articolo in rivista Vai
2019 miR-22 suppresses DNA ligase III addiction in multiple myeloma Articolo in rivista Vai
2019 Early blood rise in auto-antibodies to nuclear and smooth muscle antigens is predictive of prolonged survival and autoimmunity in metastatic-non-small cell lung cancer patients treated with PD-1 immune-check point blockade by nivolumab Articolo in rivista Vai
2018 The best strategy for RAS wild-type metastatic colorectal cancer patients in first-line treatment: A classic and Bayesian meta-analysis Articolo in rivista Vai
2018 MIR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells Articolo in rivista Vai
2018 Mouse models of multiple myeloma: Technologic platforms and perspectives Articolo in rivista Vai
2018 Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine Articolo in rivista Vai
2018 The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells Articolo in rivista Vai
2017 Immunomodulatory activity of microRNAs: Potential implications for multiple myeloma treatment Articolo in rivista Vai
2017 Radiotherapy prolongs the survival of advanced non-smallcell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev) Articolo in rivista Vai
2017 Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients Articolo in rivista Vai
2017 Network meta-analysis of randomized trials in multiple myeloma: Efficacy and safety in relapsed/refractory patients Articolo in rivista Vai
2016 Immune-modulating effects of bevacizumab in metastatic non-small-cell lung cancer patients Articolo in rivista Vai
2016 Systematic review and meta-analysis on targeted therapy in advanced pancreatic cancer Articolo in rivista Vai
2016 The route to solve the interplay between inflammation, angiogenesis and anti-cancer immune response Articolo in rivista Vai
2016 Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation Articolo in rivista Vai
2016 Immunotherapy of colorectal cancer: New perspectives after a long path Articolo in rivista Vai
2016 Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients Articolo in rivista Vai
2016 A 13 mer LNA-i-miR-221 inhibitor restores drug sensitivity in melphalan-refractory multiple myeloma cells Articolo in rivista Vai
2016 A gene expression inflammatory signature specifically predicts multiple myeloma evolution and patients survival Articolo in rivista Vai
2016 OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes Articolo in rivista Vai
2016 Pharmacokinetics and pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in mice and non-human primates Articolo in rivista Vai
2016 Identification of polymorphic variants associated with erlotinib-related skin toxicity in advanced non-small cell lung cancer patients by DMET microarray analysis Articolo in rivista Vai
2016 Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse Articolo in rivista Vai
2016 Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients Articolo in rivista Vai
2015 A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate? Articolo in rivista Vai
2015 Selective targeting of IRF4 by synthetic microRNA-125b-5p mimics induces anti-multiple myeloma activity in vitro and in vivo Articolo in rivista Vai
2015 miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies Articolo in rivista Vai
2015 Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients Articolo in rivista Vai
2015 Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts Articolo in rivista Vai
2014 Myeloid derived suppressor cells in multiple myeloma: Preclinical research and translational opportunities Articolo in rivista Vai
2014 A p53-Dependent Tumor Suppressor Network Is Induced by Selective miR-125a-5p Inhibition in Multiple Myeloma Cells Articolo in rivista Vai
2014 Gemcitabine, oxaliplatin, levofolinate, 5-fluorouracil, granulocyte-macrophage colony-stimulating factor, and interleukin-2 (GOLFIG) versus FOLFOX chemotherapy in metastatic colorectal cancer patients: The GOLFIG-2 multicentric open-label randomized phase III trial Articolo in rivista Vai
2014 Pegylated liposomal doxorubicin in the management of ovarian cancer: A systematic review and metaanalysis of randomized trials Articolo in rivista Vai
2013 Systemic inlammatory status at baseline predicts bevacizumab beneit in advanced non-small cell lung cancer patients Articolo in rivista Vai
2013 Immunologic microenvironment and personalized treatment in multiple myeloma Articolo in rivista Vai
2013 A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: Do we still need it? Articolo in rivista Vai
2013 miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease Articolo in rivista Vai
2013 Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: A meta-analysis of randomised trials Articolo in rivista Vai
2013 Target Therapy in Platinum-Refractory/Resistant Ovarian Cancer: From Preclinical Findings to Current Clinical Practice Articolo in rivista Vai
2012 Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients Articolo in rivista Vai
2012 Tumor infiltration by chemokine receptor 7 (CCR7)+ T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer Articolo in rivista Vai
2012 Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro Articolo in rivista Vai
2012 Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma Articolo in rivista Vai
2011 Phase II trial of bevacizumab and dose/dense chemotherapy with cisplatin and metronomic daily oral etoposide in advanced non-small-cell-lung cancer patients Articolo in rivista Vai