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The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity

  • Autori: Accardi Giulia, Aiello Anna, Aprile Stefano, Caldarella Rosalia, Cammarata Giuseppe, Carru Ciriaco, Caruso Calogero, Ciaccio, Marcello, Colomba Paolo, Galimberti Damiano, Gambino Caterina Maria, Davinelli Sergio, De Vivo Immaculata, Ligotti Mattia Emanuela, Vasto Sonya, Zinellu Angelo, Candore Giuseppina
  • Anno di pubblicazione: 2020
  • Tipologia: Articolo in rivista
  • OA Link:


This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.