Salta al contenuto principale
Passa alla visualizzazione normale.

SONYA VASTO

Triggering of Toll-like receptors in the elderly. A pilot study relevant for vaccination

  • Autori: Gambino, C.; Vasto, S.; Ioannou, K.; Candore, G.; Caruso, C.; Farzaneh, F.
  • Anno di pubblicazione: 2017
  • Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)
  • OA Link: http://hdl.handle.net/10447/251196

Abstract

The impaired ability of the elderly to mount an efficient immune response after exposure to microbes or vaccines represents a major challenge in protection against pathogens in ageing. Recently studies have shown that stimulation of Toll-like receptors (TLRs), using stimulatory ligands, can enhance vaccine efficacy by a number of mechanisms, including the activation of innate immune cells and the consequent production of inflammatory cytokines.