Salta al contenuto principale
Passa alla visualizzazione normale.


Triggering of Toll-like receptors in the elderly. A pilot study relevant for vaccination

  • Autori: Gambino Caterina Maria, ; Vasto, S.; Ioannou, K.; Candore, G.; Caruso, C.; Farzaneh, F.
  • Anno di pubblicazione: 2017
  • Tipologia: Contributo in atti di convegno pubblicato in volume
  • OA Link:


The impaired ability of the elderly to mount an efficient immune response after exposure to microbes or vaccines represents a major challenge in protection against pathogens in ageing. Recently studies have shown that stimulation of Toll-like receptors (TLRs), using stimulatory ligands, can enhance vaccine efficacy by a number of mechanisms, including the activation of innate immune cells and the consequent production of inflammatory cytokines.