The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
- Autori: Pereira, L.P.; Köhler, C.A.; de Sousa, R.T.; Solmi, M.; de Freitas, B.P.; Fornaro, M.; Machado-Vieira, R.; Miskowiak, K.W.; Vieta, E.; Veronese, N.; Stubbs, B.; Carvalho, A.F.
- Anno di pubblicazione: 2017
- Tipologia: Review essay (rassegna critica)
- OA Link: http://hdl.handle.net/10447/460322
Abstract
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach. © 2017 Elsevier Ltd