Salta al contenuto principale
Passa alla visualizzazione normale.

PASQUALE MANSUETO

Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19

  • Autori: Ragusa, Francesco Saverio; Solimando, Luisa; Mandalà, Caterina; Masnata, Roberta; Ciulla, Gregorio; Ciriminna, Stefano; La Blasca, Francesco; Mansueto, Pasquale; Veronese, Nicola; Barbagallo, Mario
  • Anno di pubblicazione: 2023
  • Tipologia: Articolo in rivista
  • Parole Chiave: Antibiotic; Infectious diseases; Multidimensional prognostic index; Prognosis
  • OA Link: http://hdl.handle.net/10447/584897

Abstract

Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics' cost and the prevalence of MDR (multidrug resistance) pathogens. Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months. Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p < 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics. Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics' cost.