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A Poly-L-Lactide scaffold with continuous gradient pore size for osteochondral regeneration validated in a microphysiological tissue system bioreactor

  • Autori: Gottardi, R.; Conoscenti, G.; Alexander, P.; Manner, P.; LA CARRUBBA, V.; Brucato, V.; Tuan, R.
  • Anno di pubblicazione: 2016
  • Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)
  • OA Link:


A microphysiological tissue system (MPS) bioreactor has been developed to replicate in vitro the in vivo OC physiological conditions. The MPS allows separate control of the chondral and osseous environment while permitting communication between chondrocytes and osteoblasts across the OC junction, similar to the conditions of OC tissue in vivo. We have used here our MPS system to validate the TIPS -generated pore-gradient PLLA scaffold.