Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View
- Autori: Labbozzetta Manuela; Notarbartolo Monica; Poma Paola
- Anno di pubblicazione: 2020
- Tipologia: Review essay (rassegna critica)
- OA Link: http://hdl.handle.net/10447/413665
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present diﬀerent pharmacological approaches that our group have employed to reduce the expression/activation of this transcriptional factor and thus to restore chemo-sensitivity. Finally, we examine the latest scientiﬁc evidence found by other groups, the most signiﬁcant clinical trials regarding NF-κB, and new perspectives on the possibility to consider this transcriptional factor a valid drug target in neoplastic diseases.