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DOMENICO LIO

Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis

  • Autori: Crivello, A.; Giacalone, A.; Scola, L.; Forte, G.; Nuzzo, D.; Giacconi, R.; Cipriano, C.; Candore, G.; Mocchegiani, E.; COLONNA ROMANO, G.; Lio, D.; Caruso, C.
  • Anno di pubblicazione: 2006
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/31318

Abstract

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-β1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-β1 and IL-10 polymorphisms in atherosclerosis.