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Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study

  • Autori: Serretta, V.; Corselli, G.; Piazza, B.; Lio, D.; Gervasi, F.; Salerno, S.; Pavone Macaluso, M.
  • Anno di pubblicazione: 1993
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


A total of 62 patients at high risk for recurrence of superficial bladder cancer were selected for a study designed to compare the prophylactic efficacy of different doses and schedules of sequential intravesical instillations of epirubicin and interferon-alpha-2b and to evaluate which sequence could enhance the release of cytokines in the urine. Our investigations showed a significant increase in urinary concentrations of interleukins in patients who received the sequential intravesical administration of epirubicin and interferon-alpha-2b. Higher urinary concentrations of interleukins and a lower recurrence rate were detected in patients who received interferon-alpha-2b 24 h after epirubicin instillation. © 1993 Springer-Verlag.