CD3 immunohistochemistry is helpful in the diagnosis of giant cell arteritis
- Autori: Ciccia F.; Ferrante A.; Guggino G.; Cavazza A.; Salvarani C.; Rizzo A.
- Anno di pubblicazione: 2018
- Tipologia: Articolo in rivista
- Parole Chiave: CD3; diagnosis; giant cell arteritis; immunohistochemistry; Aged; Aged, 80 and over; Biomarkers; Biopsy; CD3 Complex; Female; Giant Cell Arteritis; Humans; Immunohistochemistry; Male; Middle Aged; Photomicrography; ROC Curve; Retrospective Studies; Temporal Arteries
- OA Link: http://hdl.handle.net/10447/399884
Abstract
Objective. To evaluate whether CD3 staining performed routinely on temporal artery biopsy specimens might improve the sensitivity of temporal artery biopsy in patients with biopsy-negative GCA. Methods. Two hundred and seventy biopsies were considered for this study, stained with haematoxylin and eosin and with an anti-CD3 antibody. Results. The addition of CD3 staining modified the sensibility and the specificity of the histologic examination in 89.47 and 95.00%, respectively, with a positive and negative predictive values of 97.00 and 79.78%. Conclusion. The addition of CD3 immunostaining to the classic histologic evaluation is accompanied by a significant increase in the sensibility with a comparable specificity. The Author(s) 2018.