NANOSTRUCTURED LIPID CARRIERS CONTAINING RILUZOLE AND PHARMACEUTICAL FORMULATIONS CONTAINING SAID PARTICLES
- Autori: Bondi', M.; Giammona, G.; Craparo, E.; Drago, F.
- Anno di pubblicazione: 2008
- Tipologia: Brevetto
- Parole Chiave: SOLID LIPID NANOPARTICLES, BRAIN TARGETING, RILUZOLE
- OA Link: http://hdl.handle.net/10447/37888
The present invention concerns the preparation, the physical-chemical, technological and pharmaceutical characterization of Riluzole-loaded nanoparticle vectors. The chosen production technology permitted to obtain these systems in a reproducible way, with high yields and low costs. In particular, a novel formulation of Riluzole loaded into lipid nanoparticles was developed which is able to carry to the Central Nervous System a higher amount of drug in comparison with the free drug. In vivo results demonstrated that the administration on rats of these formulation permits to obtain a lower deposit of Riluzole in organs such as liver, spleen, heart and kidneys; the consequence is a reduction of side effects which actually are related with the administration of the free drug.