Prevalence of Toscana sand fly virus antibodies in neurological patients and control subjects in Sicily
- Autori: Colomba, C.; Saporito, L.; Ciufolini, M.; Marchi, A.; Rotolo, V.; DE GRAZIA, S.; TITONE LANZA DI SCALEA, L.; Giammanco, G.
- Anno di pubblicazione: 2012
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: Toscana virus, Sicily
- OA Link: http://hdl.handle.net/10447/64900
Toscana sandfly fever virus (TOSV) is an arthropod-borne virus transmitted to humans by sandfly vectors. It has been associated with human cases of meningitis and meningo-encephalitis mainly occurring during the warm season. We performed a retrospective serological study to evaluate TOSV circulation in Palermo, Sicily, and to compare TOSV seroprevalence in patients with neurological symptoms and in a control group of patients without neurological symptoms. When sera from 155 patients with and without neurological symptoms were evaluated, the rate of overall TOSV IgG reactivity was 17.4%. Patients with neurological symptoms showed a higher percentage of TOSV IgG positivity than control patients (25% versus 10.8%). TOSV exposure was confirmed by virus neutralization tests which also detected a Naples virus (SFNV) infection. TOSV should be considered as an etiologic agent in the differential diagnosis of fever and meningo-encephalitis in Sicily.