Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection
- Autori: Saccone G.; Sen C.; Di Mascio D.; Galindo A.; Grunebaum A.; Yoshimatsu J.; Stanojevic M.; Kurjak A.; Chervenak F.; Suarez M.J.R.; Gambacorti-Passerini Z.M.; de los Angeles Anaya Baz M.; Galan E.V.A.; Lopez Y.C.; Luis J.A.D.L.; Hernandez I.C.; Herraiz I.; Villalain C.; Venturella R.; Rizzo G.; Mappa I.; Gerosolima G.; Hellmeyer L.; Konigbauer J.; Ameli G.; Frusca T.; Volpe N.; Schera G.B.L.; Fieni S.; Esposito E.; Simonazzi G.; Di Donna G.; Youssef A.; Gatta A.N.D.; Di Donna M.C.; Chiantera V.; Buono N.; Sozzi G.; Greco P.; Morano D.; Bianchi B.; Marino M.G.L.; Laraud F.; Ramone A.; Cagnacci A.; Barra F.; Gustavino C.; Ferrero S.; Ghezzi F.; Cromi A.; Lagana A.S.; Longo V.L.; Stollagli F.; Sirico A.; Lanzone A.; Driul L.; Cecchini F.; Xodo S.; Rodriguez B.; Mercado-Olivares F.; Elkafrawi D.; Sisti G.; Esposito R.; Coviello A.; Cerbone M.; Morlando M.; Schiattarella A.; Colacurci N.; De Franciscis P.; Cataneo I.; Lenzi M.; Sandri F.; Buscemi R.; Gattei G.; Sala F.D.; Valori E.; Rovellotti M.C.; Done E.; Faron G.; Gucciardo L.; Esposito V.; Vena F.; Giancotti A.; Brunelli R.; Muzii L.; Nappi L.; Sorrentino F.; Liberati M.; Buca D.; Leombroni M.; Di Sebastiano F.; Franchi M.; Ianniciello Q.C.; Garzon S.; Petriglia G.; Borrello L.; Nieto-Calvache A.J.; Burgos-Luna J.M.; Kadji C.; Carlin A.; Bevilacqua E.; Moucho M.; Viana Pinto P.; Figueiredo R.; Morales Rosello J.; Loscalzo G.; Martinez-Varea A.; Diago V.; Jimenez Lopez J.S.; Aykanat A.Y.; Cosma S.; Carosso A.; Benedetto C.; Bermejo A.; Feuerschuette O.H.M.; Uyaniklar O.; Ocakouglu S.R.; Atak Z.; Gunduz R.; Haberal E.T.; Froessler B.; Parange A.; Palm P.; Samardjiski I.; Taccaliti C.; Okuyan E.; Daskalakis G.; de Sa R.A.M.; Pittaro A.; Gonzalez-Duran M.L.; Guisan A.C.; Genc S.O.; Zlatohlavkova B.; Piqueras A.L.; Oliva D.E.; Cil A.P.; Api O.; Antsaklis P.; Ples L.; Kyvernitakis I.; Maul H.; Malan M.; Lila A.; Granese R.; Ercoli A.; Zoccali G.; Villasco A.; Biglia N.; Madalina C.; Costa E.; Daelemans C.; Pintiaux A.; Cueto E.; Hadar E.; Dollinger S.; Brzezinski-Sinai N.A.; Huertas E.; Arango P.; Sanchez A.; Schvartzman J.A.; Cojocaru L.; Turan S.; Turan O.; Di Dedda M.C.; Molpeceres R.G.; Zdjelar S.; Premru-Srsen T.; Kornhauser-Cerar L.; Druskovic M.; De Robertis V.; Stefanovic V.; Nupponen I.; Nelskyla K.; Khodjaeva Z.; Gorina K.A.; Sukhikh G.T.; Maruotti G.M.; Visentin S.; Cosmi E.; Ferrari J.; Gatti A.; Luvero D.; Angioli R.; Puri L.; Palumbo M.; D'Urso G.; Colaleo F.; Rapisarda A.M.C.; Carbone I.F.; Manzoli L.; Flacco M.E.; Nazzaro G.; Locci M.; Guida M.; Sardo A.D.S.; Panici P.B.; Khalil A.; Berghella V.; Bifulco G.; Scambia G.; Zullo F.; D'Antonio F.
- Anno di pubblicazione: 2021
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/494995
Abstract
Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.