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Global validation of the WSES Sepsis Severity Score for patients with complicated intra-abdominal infections: A prospective multicentre study (WISS Study)

  • Autori: Sartelli, M.; Abu Zidan, F.; Catena, F.; Griffiths, E.; Di Saverio, S.; Coimbra, R.; Ordoñez, C.; Leppaniemi, A.; Fraga, G.; Coccolini, F.; Agresta, F.; Abbas, A.; Abdel Kader, S.; Agboola, J.; Amhed, A.; Ajibade, A.; Akkucuk, S.; Alharthi, B.; Anyfantakis, D.; Augustin, G.; Baiocchi, G.; Bala, M.; Baraket, O.; Bayrak, S.; Bellanova, G.; Beltràn, M.; Bini, R.; Boal, M.; Borodach, A.; Bouliaris, K.; Branger, F.; Brunelli, D.; Catani, M.; Che Jusoh, A.; Chichom Mefire, A.; Cocorullo, G.; Colak, E.; Costa, D.; Costa, S.; Cui, Y.; Curca, G.; Curry, T.; Das, K.; Delibegovic, S.; Demetrashvili, Z.; Di Carlo, I.; Drozdova, N.; El Zalabany, T.; Enani, M.; Faro, M.; Gachabayov, M.; Giménez Maurel, T.; Gkiokas, G.; Gomes, C.; Gonsaga, R.; Guercioni, G.; Guner, A.; Gupta, S.; Gutierrez, S.; Hutan, M.; Ioannidis, O.; Isik, A.; Izawa, Y.; Jain, S.; Jokubauskas, M.; Karamarkovic, A.; Kauhanen, S.; Kaushik, R.; Kenig, J.; Khokha, V.; Kim, J.; Kong, V.; Koshy, R.; Krasniqi, A.; Kshirsagar, A.; Kuliesius, Z.; Lasithiotakis, K.; Leão, P.; Lee, J.; Leon, M.; Lizarazu Pérez, A.; Lohsiriwat, V.; López Tomassetti Fernandez, E.; Lostoridis, E.; Mn, R.; Major, P.; Marinis, A.; Marrelli, D.; Martinez Perez, A.; Marwah, S.; Mcfarlane, M.; Melo, R.; Mesina, C.; Michalopoulos, N.; Moldovanu, R.; Mouaqit, O.; Munyika, A.; Negoi, I.; Nikolopoulos, I.; Nita, G.; Olaoye, I.; Omari, A.; Ossa, P.; Ozkan, Z.; Padmakumar, R.; Pata, F.; Pereira Junior, G.; Pereira, J.; Pintar, T.; Pouggouras, K.; Prabhu, V.; Rausei, S.; Rems, M.; Rios Cruz, D.; Sakakushev, B.; Sánchez de Molina, M.; Seretis, C.; Shelat, V.; Simões, R.; Sinibaldi, G.; Skrovina, M.; Smirnov, D.; Spyropoulos, C.; Tepp, J.; Tezcaner, T.; Tolonen, M.; Torba, M.; Ulrych, J.; Uzunoglu, M.; van Dellen, D.; van Ramshorst, G.; Vasquez, G.; Venara, A.; Vereczkei, A.; Vettoretto, N.; Vlad, N.; Yadav, S.; Yilmaz, T.; Yuan, K.; Zachariah, S.; Zida, M.; Zilinskas, J.; Ansaloni, L.
  • Anno di pubblicazione: 2015
  • Tipologia: Articolo in rivista (Articolo in rivista)
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Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.