Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations

Abstract

Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is an interesting measurement concerning the frequency of hyperglycaemic and hypoglycaemic excursions and it might contribute to describe the glycaemic control independently of fasting plasma glucose and glycated haemoglobin. Recently, continuous glucose monitoring systems have been developed that are able to measure interstitial glucose levels every 3 min for up to 2 days thus allowing a more accurate detection of both daily glucose load and variability.