Proteomics to elucidate the molecular physiology of Microbispora sp. ATCC-PTA-5024, the producer of NAI-107, a very promising lantibiotic
- Autori: Gallo, G.; Palazzotto, E.; Faddetta, T.; Renzone, G.; Monciardini, P.; Arena, S.; Giardina, A.; Alduina, R.; Pozzi, R.; Stegmann, E.; Weber, T.; Russo, A.; Sangiorgi, F.; Spinelli, G.; Sosio, M.; Scaloni, A.; Puglia, A.
- Anno di pubblicazione: 2015
- Tipologia: eedings
- OA Link: http://hdl.handle.net/10447/253830
Abstract
The filamentous actinobacterium Microbispora sp. ATCC-PTA-5024 produces the lantibiotic NAI-107 (Maffioli et al., 2014), which is effective against multidrug-resistant Gram-positive pathogens (Jabés et al., 2011). In actinomycetes, the biosynthesis of antibiotics is generally elicited as a physiological response controlled by a complex regulatory network involving global regulators, playing pleiotropic roles, and pathway-specific regulators, which activate the biosynthesis of biologically active molecules (Bibb, 2005)