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How do skeletal morbidity rate and special toxicities affect 12-week versus 4-week schedule zoledronic acid efficacy? A systematic review and a meta-analysis of randomized trials

  • Autori: Santini D.; Galvano A.; Pantano F.; Incorvaia L.; Rizzo S.; Vincenzi B.; Castellana L.; Giuliana G.; Guadagni F.; Toia F.; Tonini G.; Russo A.; Badalamenti G.; Bazan V.
  • Anno di pubblicazione: 2019
  • Tipologia: Articolo in rivista
  • Parole Chiave: AEs; Bone metastases; Breast; Meta-Analysis; Prostate; SMR; Solid tumors; Zoledronic acid; Bone Density Conservation Agents; Bone Neoplasms; Breast Neoplasms; Female; Humans; Male; Prostatic Neoplasms; Treatment Outcome; Zoledronic Acid
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Background: Zoledronic Acid is a bisphosphonate used in a 4-week schedule for the treatment of bone metastases. Some randomized trials supported its role also when administered every 12 weeks. Methods: we performed a systematic review and a meta-analysis in order to evaluate the two different schedules in terms of skeletal morbidity rate (SMR), skeletal related events (SRE) and adverse events (AEs). Results: our results showed a clinical difference favouring the 12-week schedule in terms of AEs (RR 1.17, 95% CI 1.06–1.29). No signifcant differences were found for SMR (RR 0.97, 95% CI 0.84–1.13) and SRE (RR 1.02, 95% CI 0.89–1.16). Conclusions: Our findings support in clinical practice the 12-week schedule an alternative to the standard 4-week schedule in advanced breast and prostate cancer, in particular when the clinical comorbidities of the patients suggest a higher risk of renal failure or hypocalcaemia.