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ANTONINO TUTTOLOMONDO

Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: relationship with TOAST subtype, outcome and infarct site

  • Autori: Tuttolomondo, A.; Di Sciacca, R.; DI RAIMONDO, D.; Serio, A.; D’Aguanno, G.; La Placa, S.; Percoraro, R.; Arnao, V.; Marino, L.; Monaco, S.; Natalè, E.; Licata, G.; Pinto, A.
  • Anno di pubblicazione: 2009
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: stroke, TOAST subtype
  • OA Link: http://hdl.handle.net/10447/49221

Abstract

BACKGROUND: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. MATERIALS AND METHODS: We evaluated plasma levels of IL-1beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. RESULTS: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1beta. CONCLUSIONS: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables.