Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids
- Autori: Amedea Manfredi; Nicolò Mauro; Alessio Terenzi; Jenni Alongi; Federica Lazzari ; Fabio Ganazzoli ; Giuseppina Raffaini ; Elisabetta Ranucci ; Paolo Ferruti
- Anno di pubblicazione: 2017
- Tipologia: Articolo in rivista (Abstract in rivista)
- OA Link: http://hdl.handle.net/10447/240593
This paper reports on synthesis, acid–base properties and pH-dependent structuring in water of d-, l- and d,l-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N′-methylenebis(acrylamide). The circular dichroism spectra of d- and l-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribution at pH 6 and 14 consistent with the similarity of the CD spectra from pH 6 upward.