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ALESSIO TERENZI

DNA-Binding of NiII, CuII and ZnII Complexes of Salen Derivatives

  • Autori: Terenzi, A.; Bonsignore, R.; Spinello, A.; Almerico, A.; Lauria, A.; Barone, G.
  • Anno di pubblicazione: 2014
  • Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)
  • OA Link: http://hdl.handle.net/10447/99981

Abstract

Nickel(II), copper(II) and zinc(II) complexes of N2O2 tetradentate Schiff base ligands strongly interact with B-DNA, usually by groove-binding and/or by intercalation [1]. It has been also shown that the presence of aromatic substituents on the N,N’ bridge make them suitable G-quadruplex binders [2]. In this context, we have recently investigated the binding toward duplex and G-quadruplex DNA of nickel(II), copper(II) and zinc(II) complexes of N,N’-bis-5-(triethyl ammonium methyl)-salicylidene-2,3-naphthalendiiminato) (see Figure), by spectroscopic and computational methods [3,4]. The compounds show also biological activity against human cancer cell lines. Different substituents are presently considered on the N,N’-bridge, in order to increase their selectivity towards telomeric and oncogene promoter DNA sequences, rather than toward B-DNA, and to target G-quadruplexes on the grooves rather than by π-π stacking.