Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials
- Autori: Saladino, Maria Luisa; Markowska, Marta; Carmone, Clara; Cancemi, Patrizia; Alduina, Rosa; Presentato, Alessandro; Scaffaro, Roberto; Biały, Dariusz; Hasiak, Mariusz; Hreniak, Dariusz; Wawrzyńska, Magdalena
- Anno di pubblicazione: 2020
- Tipologia: Articolo in rivista
- OA Link: http://hdl.handle.net/10447/423277
Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.