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GIORGIO STASSI

Role of Th cytokines in thyroid autoimmunity

  • Autori: Francipane, M.; Lombardo, Y.; LO MONTE, A.; Todaro, M.; Stassi, G.
  • Anno di pubblicazione: 2007
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: THYROID AUTOIMMUNE DESEASE, CYTOKINE
  • OA Link: http://hdl.handle.net/10447/44456

Abstract

Thyroid autoimmunity occurs when the immune system reacts against thyroid cells after targeting them like any other “not-self” antigen. To define a thyroid autoimmune disorder is often difficult even if the presence of auto-antibodies and/or autoreactive lymphocytes is a common feature. Although the pathogenetic mechanism is poorly understood, increasing evidences indicate that apoptosis is one of the key process that leads to thyroid auto-immunity. Afterward, Th cytokines have been considered the regulator factors of the cell survival in thyroid autoimmunity. Understanding the cell response from the perspective of type 1 or type 2 cytokines could clarify the pathogenetic mechanism controlling thyroid autoimmunity and define new therapeutic approaches