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Nutritional epigenomic and DNA-damage modulation effect of natural stilbenoids

  • Autori: Volpes, Sara; Cruciata, Ilenia; Ceraulo, Federica; Schimmenti, Chiara; Naselli, Flores; Pinna, Cecilia; Mauro, Maurizio; Picone, Pasquale; Dallavalle, Sabrina; Nuzzo, Domenico; Pinto, Andrea; Caradonna, Fabio
  • Anno di pubblicazione: 2023
  • Tipologia: Articolo in rivista
  • OA Link:


The aim of the present work is the evaluation of biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. In the present study, resveratrol, pterostilbene and for the first time their dimers (±)-trans-δ-viniferin, (±)-trans-pterostilbene dehydrodimer were evaluated in Caco-2 and HepG-2 cell lines as potential epigenetic modulators. Stilbenoids were added in a Caco-2 cell culture as a model of the intestinal epithelial barrier and in the HepG-2 as a model of hepatic environment, to verify their dose-dependent toxicity, ability to interact with DNA, and epigenomic action. Resveratrol, pterostilbene, and (±)-trans-pterostilbene dehydrodimer were found to have no toxic effects at tested concentration and were effective in reversing arsenic damage in Caco-2 cell lines. (±)-trans-δ-viniferin showed epigenomic activity, but further studies are needed to clarify its mode of action.