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PIETRO MESSINA

CAPSAICIN STIMULATION AND NEUROGENIC EXPERIMENTALLY INDUCED INFLAMMATION OF THE HUMAN LABIAL MUCOSA

Abstract

Background. The neurogenic inflammation depends on the neuromodulator release by peripheral nervous termi−nations. A series of different studies proved the existence of a neurogenic phlogosis (NP) in different body sites.Only experiences on rat managed to induce NP at the oral mucosa level.Objectives. Inducing NP at the human mucosa level.Material and Methods. Two groups of patients (group A: M/F: 8/7; mean: 41.14 ± 12.4; range: 24–60; group B:M/F: 8/7; mean: 41.21 ± 12.39; range: 23–60) were examined in authors’ laboratory. The NP was experimentallyinduced at the lower lip mucosa level after topically applying capsaicin. The vascular consequences were observedthrough computer videocapillaroscopy techniques (Videocap 100). The lip mucosa of the group A patients wasobserved in three different time periods: before capsaicin application (t0), after one minute (t1), and after 45 min−utes (t2) from capsaicin application. The lip mucosa of the group B patients was observed in four different timeperiods: before capsaicin application (t0), after local anaesthetic injected (t1), after one minute (t2) and after 45 min−utes (t3) from capsaicin application.Results. The vascular in vivo observation, in the group A, allows to highlight after one minute application only, theaxono−reflected vasodilation, the real expression of NP. After 45 minutes, the vascular diameter returned to its ini−tial diameter. In the group B, the vascular in vivo study allows to observe no significant modification of the vas−cular diameter in the four different time periods.Conclusions. The study highlights that the NP can be induced at the human oral cavity level and such an evidencecould be extremely important in the pathogenesis and treatment of the different oral pathologies