Cytotoxic activity of some natural and synthetic guaianolides
- Autori: Bruno, M.; Rosselli, S.; Maggio, A.; Raccuglia, R.; BASTOW K., F.; Lee, K.
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/9794
Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain