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Cytotoxic activity of some natural and synthetic guaianolides

  • Autori: Bruno, M.; Rosselli, S.; Maggio, A.; Raccuglia, R.; BASTOW K., F.; Lee, K.
  • Anno di pubblicazione: 2005
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain