Cytotoxic activity of some natural and syntetic sesquiterpene lactones
- Autori: Bruno, M.; Rosselli, S.; Maggio, A.; Raccuglia, R.; Bastow, K.; WU C., C.; Lee, K.
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/5499
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.