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Cytotoxic activity of some natural and syntetic sesquiterpene lactones

  • Autori: Bruno, M.; Rosselli, S.; Maggio, A.; Raccuglia, R.; Bastow, K.; WU C., C.; Lee, K.
  • Anno di pubblicazione: 2005
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.