Perfusion MR Imaging in Differentiating High-Grade from Low-Grade Gliomas
- Autori: Sparacia, G.; Purpura, P.; DI GIOVANNA, E.; Lagalla, R.
- Anno di pubblicazione: 2011
- Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)
- Parole Chiave: Glioma; perfusion; low -grade/high-grade
- OA Link: http://hdl.handle.net/10447/76944
To correlate perfusion MR imaging with histologic grade of cerebral gliomas. Materials & Methods Relative cerebral blood volume (rCBV) maps were determined in 22 patients with pathologically proved gliomas (11 glioblastomas, 8 anaplastic gliomas and 2 low-grade gliomas) by dynamic contrast-enhanced T2*-weighted MR imaging. MR examination was completed with conventional T1- and T2-weighted imaging. The rCBV maps were calculated with an independent workstation by fitting a gamma-variate function to the contrast material concentration versus time curve. Relative CBV ratios obtained between tumor and normal white matter were compared between glioblastomas, anaplastic gliomas and low-grade gliomas by means of receiver operating characteristic (ROC) analysis. Results Mean rCBV ratios were 4.85 (± 1) for glioblastomas, 3.87 (± 0.7) for anaplastic gliomas and 1.65 (± 1.6) for low-grade gliomas. Receiver operating characteristic analysis demonstrates significant differences between glioblastomas and anaplastic gliomas (p<.05), between anaplastic gliomas and low-grade gliomas (p<.05) and between glioblastomas and low-grade gliomas (p<.01). The rCBV ratio cutoff value between highgrade gliomas and low-grade gliomas was 2.52 with a sensitivity and specificity of 100% and 75% respectively. Conclusion Perfusion MR imaging is a reliable technique for differentiating high-grade from low-grade gliomas