DNA-Binding of NiII, CuII and ZnII Complexes of Salen Derivatives
- Autori: Terenzi, A; Bonsignore, R; Spinello, A; Almerico, AM; Lauria, A; Barone, G
- Anno di pubblicazione: 2014
- Tipologia: eedings
- OA Link: http://hdl.handle.net/10447/99981
Nickel(II), copper(II) and zinc(II) complexes of N2O2 tetradentate Schiff base ligands strongly interact with B-DNA, usually by groove-binding and/or by intercalation . It has been also shown that the presence of aromatic substituents on the N,N’ bridge make them suitable G-quadruplex binders . In this context, we have recently investigated the binding toward duplex and G-quadruplex DNA of nickel(II), copper(II) and zinc(II) complexes of N,N’-bis-5-(triethyl ammonium methyl)-salicylidene-2,3-naphthalendiiminato) (see Figure), by spectroscopic and computational methods [3,4]. The compounds show also biological activity against human cancer cell lines. Different substituents are presently considered on the N,N’-bridge, in order to increase their selectivity towards telomeric and oncogene promoter DNA sequences, rather than toward B-DNA, and to target G-quadruplexes on the grooves rather than by π-π stacking.