NT pro BNP plasma level and atrial volume are linked to the severity of liver cirrhosis.
- Autori: Licata, A.; Corrao, S.; Petta, S.; Genco, C.; Cardillo, M.; Calvaruso, V.; Cabibbo, G.; Massenti, M.F.; Camma', C.; Licata, G.; Craxi, A.
- Anno di pubblicazione: 2013
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/88184
Abstract
Background and Aims: Plasma levels of NT-pro-BNP, a natriuretic peptide precursor, are raised in the presence of fluid retention of cardiac origin and can be used as markers of cardiac dysfunction. Recent studies showed high levels of NT pro BNP in patients with cirrhosis. We assessed NT pro-BNP and other parameters of cardiac dysfunction in patients with cirrhosis, with or without ascites, in order to determine whether the behaviour of NT pro BNP is linked to the stage of liver disease or to secondary cardiac dysfunction.Methods: Fifty eight consecutive hospitalized patients mostly with viral or NAFLD-related cirrhosis were studied. All underwent abdominal ultrasound and upper GI endoscopy. Cardiac morpho-functional changes were evaluated by echocardiography and NT-pro-BNP plasma levels determined upon admission. Twenty-eight hypertensive patients, without evidence of liver disease served as controls.Results: Fifty eight cirrhotic patients (72% men) with a median age of 62 years (11% ...