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Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm.

  • Autori: Alafaci, C.; Salpietro, F.; Iacopino, D.; Edvinsson, L.; Tomasello, F.
  • Anno di pubblicazione: 1991
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.