Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C
- Autori: Petta, S; Rosso, C; Leung, R; Abate, M; Booth, D; Salomone, F; Gambino, R; Rizzetto, M; Caviglia, P; Smedile, A; Grimaudo, S; Cammà , C; Craxì, A; George, J; Bugianesi, E
- Anno di pubblicazione: 2013
- Tipologia: Articolo in rivista (Articolo in rivista)
- Parole Chiave: insulin resistance, steatosis, interleukin-28B, sustained virologic response
- OA Link: http://hdl.handle.net/10447/73825
Abstract
Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.