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Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C

  • Autori: Petta, S.; Rosso, C.; Leung, R.; Abate, M.; Booth, D.; Salomone, F.; Gambino, R.; Rizzetto, M.; Caviglia, P.; Smedile, A.; Grimaudo, S.; Camma', C.; Craxi, A.; George, J.; Bugianesi, E.
  • Anno di pubblicazione: 2013
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: insulin resistance, steatosis, interleukin-28B, sustained virologic response
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Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the interaction between IL28B genotype and IR, and their combined effects on SVR, have not been defined. We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR.