Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells
- Autori: SIMONI D; GIANNINI G; ROBERTI M; RONDANIN R; BARUCHELLO R; ROSSI M; GRISOLIA G; INVIDIATA FP; AIELLO S; MARINO S; CAVALLINI S; SINISCALCHI A; GEBBIA N; CROSTA L; GRIMAUDO S; ABBADESSA V; DI CRISTINA A; TOLOMEO M
- Anno di pubblicazione: 2005
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/16498
Abstract
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.