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MICHELANGELO GRUTTADAURIA

The binary pyrene/heptakis-(6-amino-6-deoxy)-β-cyclodextrin complex: A suitable chiral discriminator. Spectrofluorimetric study of the effect of some α-amino acids and esters on the stability of the binary complex

  • Autori: D'Anna, F.; Riela, S.; Meo, L.; Gruttadauria, M.; Noto, R.
  • Anno di pubblicazione: 2002
  • Tipologia: Articolo in rivista
  • OA Link: http://hdl.handle.net/10447/373279

Abstract

The effect of some α-amino acids and their esters on the stability of the binary pyrene/heptakis-(6-amino-6-deoxy)-β-cyclodextrin (py/am-β-CD) complex has been studied by means of fluorescence spectroscopy at two pH values (8.0 and 9.0). The binary complex was generally stabilized by adding the ternary agent at pH 8.0. A more varied substrate effect is observed at pH 9.0 where am-β-CD is present in the uncharged form. The conditional constant (β2) values determined by l/d α-amino acids show that the binary complex is a suitable receptor for chiral recognition. The enantiomer selectivity values obtained, ranging from 1.2 up to 7.4, are generally higher than those reported for α-amino acids and their derivatives by modified cyclodextrins.