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MICHELANGELO GRUTTADAURIA

Binding equilibria between beta-cyclodextrin and p-nitro-aniline derivatives: the first systematic study in mixed water-methanol solvent systems.

  • Autori: LO MEO, P.; D'Anna, F.; Riela, S.; Gruttadauria, M.; Noto, R.
  • Anno di pubblicazione: 2009
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/36852

Abstract

Complexation equilibria, in mixed water-methanol solvent media, between native β-cyclodextrin and a set of suitably selected p-nitro-aniline derivatives were studied by means of polarimetry. The effects exerted by the organic co-solvent on the conditional inclusion free energies ΔGcond 0 and the differential molar optical rotations ΔΘ were thoroughly analyzed under the perspective of the enthalpy-entropy compensation effect. Experimental data suggest an intimate participation ('dynamic co-inclusion') of solvent molecules in the formation and in the conformational dynamics of the host-guest inclusion complex.