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Triiodothyronine‐Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium

  • Autori: Cestelli, A.; DI LIEGRO, I.; Castiglia, D.; Gristina, R.; Ferraro, D.; Salemi, G.; Savettieri, G.
  • Anno di pubblicazione: 1987
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: Chemically denned medium); Chromatin structure; Neuronal terminal differentiation; Triiodothyronine; Biochemistry; Cellular and Molecular Neuroscience
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Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one. Copyright © 1987, Wiley Blackwell. All rights reserved