Targeting of the Peritumoral Adipose Tissue Microenvironment as an Innovative Antitumor Therapeutic Strategy
- Autori: Lo Iacono M.; Modica C.; Porcelli G.; Brancato O.R.; Muratore G.; Bianca P.; Gaggianesi M.; Turdo A.; Veschi V.; Todaro M.; Di Franco S.; Stassi G.
- Anno di pubblicazione: 2022
- Tipologia: Review essay (rassegna critica)
- OA Link: http://hdl.handle.net/10447/557957
Abstract
The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of TME, and contributes to cancer development and progression. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), drive cancer progression by releasing metabolites and inflammatory adipokines. In this review, we highlight the mechanisms underlying the bidirec-tional crosstalk among CAAs, CSCs, and stromal cells. Moreover, we focus on the recent advances in the therapeutic targeting of adipocyte-released factors as an innovative strategy to counteract cancer progression.