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Nation-wide surveillance study of Human Astrovirus infections in Italian paediatric population

  • Autori: DE GRAZIA, S.; Martella, V.; Chironna, M.; Bonura, F.; Tummolo, F.; Calderaro, A.; Moschidu, P.; Giammanco, G.; Medici, M.
  • Anno di pubblicazione: 2012
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link:


The study investigated the genetic diversity of human astroviruses (HAstVs) detected in children hospitalized with gastroenteritis in Italy in 2008–2009. A total of 1321 faecal samples were collected in Parma (northern Italy), Bari (southern Italy), and Palermo (Sicily) and screened for the presence of HAstVs. RT–PCR amplification of a portion at the 5k-end of ORF2 allowed the detection of HAstVs in 3.95% of the patients. Four different genotypes (HAstV-1, HAstV-2, HAstV-4, HAstV-5) were found to be circulating during the study period, with HAstV-1 being the predominant type. Interestingly, a novel lineage, proposed as HAstV-2d, was found to have emerged in Parma in 2009. Investigating the genetic variability of HAstVs will be important for understanding the epidemiological trends and evolution of these viruses.