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SIMONA DE GRAZIA

Genetic characterization of G3 rotaviruses detected in Italian children in the years 1993–2005

  • Autori: DE GRAZIA, S.; Martella, V.; Colomba, C.; Cascio, A.; Arista, S.; Giammanco, G.
  • Anno di pubblicazione: 2009
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • Parole Chiave: rotavirus G3P[8]; sequence analysis; NSP4; gastroenteritis; Italy
  • OA Link: http://hdl.handle.net/10447/42768

Abstract

In recent years an apparent increase in the frequency of detection of G3P[8] rotaviruses has been observed worldwide. Similarly, in Italy G3P[8] strains have been detected sporadically and in a scattered fashion over 20 years, whereas in 2003 and 2005 G3P[8] rotavirus activity increased markedly. By analysis of the VP7, VP4, VP6, and NSP4 genes of a selection of G3P[8] rotaviruses detected between 1993 and 2005, a remarkable sequence conservation was observed in the VP7, VP4, and VP6 genes. By converse, after 2002 the Italian G3P[8] strains were found to possess unique mutations in significant regions of the NSP4 protein.