Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles
- Autori: Barraja, P.; Diana, P.; Lauria, A.; Montalbano, A.; Almerico, A.; Dattolo, G.; Cirrincione, G.
- Anno di pubblicazione: 2004
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/32873
A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.