Synthesis and Antiproliferative Activity of [1,2,4]triazino[4,3-a]indoles
- Autori: BARRAJA P; DIANA P; LAURIA A; MONTALBANO A; ALMERICO AM; DATTOLO G; CIRRINCIONE G
- Anno di pubblicazione: 2004
- Tipologia: Articolo in rivista (Articolo in rivista)
- OA Link: http://hdl.handle.net/10447/32873
Abstract
A series of [1,2,4]triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.