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PATRIZIA DIANA

SYNTHESIS AND PHOTOCHEMIOTHERAPEUTIC ACTIVITY OF THIOPYRANO[2,3-E]INDOL-2-ONES

  • Autori: Barraja, P.; Sciabica, L.; Diana, P.; Lauria, A.; Montalbano, A.; Almerico, A.; Dattolo, G.; Cirrincione, G.; Disaro, S.; Basso, G.; Viola, G.; Dall'Acqua, F.
  • Anno di pubblicazione: 2005
  • Tipologia: Articolo in rivista (Articolo in rivista)
  • OA Link: http://hdl.handle.net/10447/21203

Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.