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GIUSEPPE DAIDONE

Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound

  • Autori: Maggio, B.; Raimondi, M.; Cascioferro, S.; Scherrmann, M.; Prosa, N.; Lauricella, M.; Carlisi, D.; Daidone, G.
  • Anno di pubblicazione: 2014
  • Tipologia: Proceedings (TIPOLOGIA NON ATTIVA)

Abstract

A new polycylic compound was synthesized and evaluated for its antiproliferative activity against the NCI panel of human tumoral cell lines showing IC50 values in the range 0.47-5.43 µM. The compound induced a decrease of the level of cyclin B1, whereas increased the level of the inhibitor p21 WAF1

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