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Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound

  • Autori: Maggio, B; Raimondi, MV; Cascioferro, S; Scherrmann, MC; Prosa, N; Lauricella, M; Carlisi, D; Daidone, G
  • Anno di pubblicazione: 2014
  • Tipologia: eedings
  • OA Link:


A new polycylic compound was synthesized and evaluated for its antiproliferative activity against the NCI panel of human tumoral cell lines showing IC50 values in the range 0.47-5.43 µM. The compound induced a decrease of the level of cyclin B1, whereas increased the level of the inhibitor p21 WAF1